Jonathan Douros​

Postdoctoral Fellow, Duke University Molecular Physiology Institute

I am a postdoctoral scholar in Dr. David D'Alessio's laboratory located within the Duke Molecular Physiology Institute (DMPI). My research interests focus broadly on the endocrine regulation of metabolism. More specifically I am interested in the gastrointestinal control of glucose metabolism with two arms to my current projects. The first is to describe the cellular mechanisms by which glucose sensitivity and insulin secretion are improved following bariatric surgeries. The second is to assess mechanisms through which bariatric changes to gut anatomy act to regulate the pancreatic islet; specifically I am interested in how increased levels of incretin hormones like glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP) regulate the islet following bariatric procedures. My position in Dr. D'Alessio's lab, a respected clinical endocrinologist and eminent incretin biologist, and within the highly collaborative environment of the DMPI have ideally positioned me to advance these research aims using an array of technical approaches from in vivo animal physiology and ex vivo islet physiology to integrated multi-omics analyses.