Jonathan Douros​

Postdoctoral Fellow, Duke University Molecular Physiology Institute

Jonathan Douros, Ph.D.
Duke Molecular Physiology Institute
300 N. Duke St., Durham NC
919-796-4057
jonathan.douros@dm.duke.edu

Education and Training
2015 Postdoctoral Scholar, Duke Molecular Physiology Institute
2015 Ph.D.  Zoology, North Carolina State University, Raleigh N.C. (Minors in Physiology & Molecular Biotechnology)
2010 B.S. Biology, Shaw University, Raleigh N.C. (Magna Cum Laude)

Publications
Douros, J.D., Baltzegar, D.A., Reading, B.J., Borski, R.J. Novel role of leptin to stimulate glycolysis through STAT3 dependent mechanism in vertebrates. In preparation.  
Anderson, K.A., Huynh, F.K., Fisher-Wellman, K., Stuart, J.D., Peterson, B.S., Douros, J.D., Wagner, G.R., Thompson, J.W., Madsen, A.S., Green, M.F., Sivley, R.M., Ilkayeva, O.R., Stevens, R.D., Backos, D.S., Capra, J.A., Olsen, C.A., Campbell, J.E., Muoio, D.M., Grimsrud, P.A., Hirschey, M.D. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Accepted for publication 01/30/2017 by Cell Metabolism (manuscript #D-17-00071).
Douros J.D., Baltzegar DA, Reading BJ, et al., Metabolic stress stimulates leptin A (LepA) in the tilapia (Oreochromis mossambicus): Implications for the regulatory interaction between LepA and the hepatosomatic growth axis. Gen Comp Endocrinology 240, 227-237 (2017). PMID 27449341.
Won, E.T., Douros, J.D., Hurt, D.A., Borski, R.J. Leptin stimulates hepatic growth hormone receptor and insulin-like growth factor gene expression in a teleost fish. Gen Comp Endocrinology 229, 84-91 (2016). PMID 26853487.
Douros, J.D., Baltzegar, D.A., Breves, J.P., Lerner, D.T., Seale, A.P., Gordon Grau, E. & Borski, R.J. Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: Studies utilizing a homologous Leptin A ELISA in the tilapia. Gen Comp Endocrinol (2014). PMID 24662392.
Baltzegar, D.A., Reading, B.J., Douros, J.D. & Borski, R.J. Role for leptin in promoting glucose mobilization during acute hyperosmotic stress in teleost fishes. Journal of Endocrinology 220, 61-72 (2014). PMID 24194509

Fellowships, Scholarships, and Awards
2017: Ruth L. Kirschstein NRSA Individual Postdoctoral Fellowship (1F32DK115031-01) National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
2016: Ruth L. Kirschstein NRSA Institutional Research Training Grant (T32DK007012) National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
2016: Duke-National University of Singapore Postdoctoral Research Exchange Program Fellowship
2015: Best Presentation Runner-up: North American Society of Comparative Endocrinologists Biennial Meeting 
2015: Travel Award: North American Society of Comparative Endocrinologists Biennial Meeting 
2015 Certificate of Accomplishment in Teaching Program (N.C. State University)
2013: Graduate Teaching Assistantship (N.C. State University)
2011: GAANN Fellow (U.S. Department of Education)
2009: Medical Education Development Program Scholar (UNC-CH School of Medicine)
2007: Athletic Scholarship, Basketball (Shaw University)

Presentations

​2017: Does Bariatric Surgery Build Better Beta Cells? Vertical Sleeve Gastrectomy Stimulates Autonomous Improvements to Islet Function in Mice. Douros, J.D., Niu, J., Sdao, S., Campbell, J., Merrins, M. Tong, J., D'Alessio, D. American Diabetes Association 77th Scientific Sessions

2017: Increased Glucose-Dependent Insulinotropic Polypeptide (GIP) Secretion and Signaling Improves Beta-Cell Function following Vertical Sleeve Gastrectomy (VSG). Douros, J.D., Niu, J., Campbell, J., Tong, J., D'Alessio, D. Keystone Gastrointestinal Control of Metabolism  (Z6) 
2015: Novel role of leptin to stimulate glycolysis through STAT3 dependent mechanism in vertebrates. Douros, J.D., Baltzegar, D.A., Reading, B.J., Borski, R.J. 3rd Biennial Conference of the North American Society for Comparative Endocrinology
2015: Who’s in charge here? How gut hormones drive the brain and behavior. Douros, J.D. North Carolina Museum of Sciences Brain Awareness Week Symposium 
2015: Novel role of leptin to stimulate glycolysis through STAT3 dependent mechanism in vertebrates. Douros, J.D., Baltzegar, D.A., Reading, B.J., Borski, R.J. W.M Keck Center for Behavioral Biology Student/Postdoctoral Fellow Symposium.
2013: Leptin Stimulates Hepatic Growth Hormone Receptors and Insulin-like Growth Factor Expression: Possible Function in Enhancing GH-Mediated Anabolic Processes in Fish. Douros, Jonathan, Won, Eugene, Baltzegar, David, Borski, Russell. The Statistics and Zoology Graduate Student Symposium
2013: Leptin Stimulates Hepatic Growth Hormone Receptors and Insulin-like Growth Factor Expression: Possible Function in Enhancing GH-Mediated Anabolic Processes in Fish. Douros, Jonathan, Won, Eugene, Baltzegar, David, Borski, Russell. World Aquaculture Society International Symposium 
2012: Development and Validation of a Homologous ELISA to Tilapia Leptin. NCSU Molecular Biotechnology Symposium
2011: Production and Purification of Recombinant Tilapia (Oreochromis mossambicus) Leptin. NCSU Molecular Biotechnology Symposium

Research Experience
2015-present: Postdoctoral Scholar, Duke University 
2010-2015: Doctoral Research, North Carolina State University
2010: Undergraduate Research, North Carolina State University
2010: Undergraduate Research, North Carolina State University

Teaching Experience 
2011-2014: Cellular and Molecular Biology Laboratory: Bio 183 
2012:  Endocrinology (Bio 492/594)
2010:  Ecology, Evolution, and Biodiversity Laboratory: Bio 181 

Undergraduate Mentorship
2015: Meredith Meyer, currently completing B.S. Biology at NCSU
2014-2015: Jordan Taylor, currently pursuing M.D. at V.A. Tech Corilian School of Medicine
2015: Alex Yllanes, currently pursuing Ph.D. Neurophysiology at East Carolina University
2012-2013 Everett Wilson, currently pursuing M.A. Physiology at NCSU

Professional/Educational Societies
North American Society for Comparative Endocrinology
The W.M. Keck Center for Behavioral Biology
American Association for the Advancement of Sciences
World Aquaculture Society
N.C. State Graduate Student Association
Alpha Chi National Honors Society